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Faculty

Faculty

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Karol Bruzik

Bruzik, Karol S.: Professor and Associate Head for Curriculum, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1980) Polish Academy of Sciences

Research interests: Bioorganic chemistry. Investigation of mechanisms of inositol-related enzymes and their function in cell signaling events. Synthesis of analogs of biophosphates as inhibitors and probes of enzyme mechanisms. Real-time, live-cell assay of enzymatic activities in response to receptor stimulation. Isolation, structure determination and synthesis of novel phosphoinositide second messengers.
kbruzik@uic.edu

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Joanna Burdette

Burdette, Joanna E.: Professor, Department of Medicinal Chemistry and Pharmacognosy; Associate Dean for Research and Graduate Education, College of Pharmacy. Ph.D. (2003) University of Illinois at Chicago

Research interests: The Burdette lab is interested in biological questions that are important for women’s health. We integrate imaging, drug discovery, and basic biology to try and understand how and where ovarian cancers originate. Our research primarily uses mouse models to understand early events in ovarian cancers. We are also using natural products to uncover new progestins and anti-cancer molecules. 
joannab@uic.edu

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CT Che

Che, Chun-Tao: Harry H.S. Fong Professor of Pharmacognosy, Department of Medicinal Chemistry and Pharmacognosy. Ph.D. (1982) University of Illinois at Chicago

Research interests: Interested in natural drugs and Chinese medicine, including: 1. Natural products chemistry: isolation, characterization, and structural elucidation of secondary metabolites from medicinal plants and other natural sources. 2. Biologically active natural substances. 3. Chemical/biological standardization and quality assessment of herbal drugs and herb-based preparations. 4. Development of analytical techniques for herbal drug analysis. 5. Development of evidence-based Chinese medicine and other natural products 
chect@uic.edu

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Stephen DiMagno

DiMagno, Stephen G: Professor, Department of Medicinal Chemistry and Pharmacognosy. Ph.D. (1991) University of California, Berkeley

Research interests:Radiopharmaceutical chemistry, medical imaging, organofluorine chemistry, kinetics, and computational chemistry.
sdimagno@uic.edu

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Alessandra Eustaquio

Eustaquio, Alessandra: Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy. Ph.D. (2004) Eberhard Karls Universität Tübingen, Germany

Research interests: Specialties: Genetic engineering, microbiology, natural product biosynthesis, drug discovery, chemical biology, synthetic biology. 
ase@uic.edu

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Michael Federle

Federle, Michael J.: Associate Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2002) Emory University, Atlanta

Research interests:Research focuses on discovering and understanding how bacteria communicate among themselves as a means for organizing group behaviors, especially behaviors facilitating the initiation and progression of disease in humans.  Cell-to-cell communication in bacteria, termed Quorum Sensing, relies on a language of small, secreted signaling molecules called autoinducers.  Bacteria detect and respond to autoinducers through various types of receptor proteins sitting atop gene regulatory networks.  it is my goal to identify and describe the production and structure of new autoinducers and their cognate signal-transduction networks that contribute to the pathogenic state of the microorganism.  Our lab will use classic bacterial genetic and molecular biology techniques combined with conventional genomic, proteomic, and metabolomic analyses to identify components and targets of these signaling systems.  Structural analysis of autoinducers and receptors, as well as screening for inhibitory compounds, will also be a focus of our work.  I am concentrating my efforts on Gram-positive pathogens, as these organisms pose the most current threat in developing resistance to multiple antibiotic treatments.  It is my hope that our research will lead to the development of new therapies that exploit and confuse communication systems bacteria use to organize attacks on the body.
mfederle@uic.edu

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Scott Franzblau

Franzblau, Scott, G.: Albert Schatz Professor and Director of the Institute for Tuberculosis Research, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1982) University of Arizona

Research interests: New drug discovery from natural and synthetic sources for tuberculosis; high throughput screening assay development; new drug target identification using proteomic and metabolomic analyses of dormant M. tuberculosis, low-tech clinical drug susceptibility assay development. 
sgf@uic.edu

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Yu Gao

Gao, Yu (Tom): Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2014) The Scripps Institute

Research interests: Chemical biology, development of novel chemical and informatics tools to investigate the proteome and complex biological system. By combining chemical screening, mass spectroscopy-based proteomics/metabolomics, and informatics, Dr. Gao’s research aims to interrogate the proteome and to elucidate protein interactions (including protein-protein and protein-small molecule interaction).
yugao@uic.edu

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Michael Johnson

Johnson, Michael E.: Professor Emeritus, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1973) Northwestern University

Research interests: Structural biology of proteins and RNA; structure-based design of therapeutic agents using modern techniques of computer-aided drug design, combinatorial expansion, in silico screening of chemical libraries and related technologies. Modern biotechnology provides an enormous range of tools for the development of new therapeutic agents to treat infectious diseases and other human ailments.
mjohnson@uic.edu

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Alexander Mankin

Mankin, Alexander S.: Professor, Department of Medicinal Chemistry and Pharmacognosy; Director, Center for Biomolecular Sciences, Ph.D. (1981) Moscow State University

Research Interests: Mechanisms of protein synthesis; structure, function and evolution of ribosome and ribosomal RNA; mechanisms of action of ribosome-targeted antibiotics.
shura@uic.edu

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Terry Moore

Moore, Terry W.: Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2008) University of Illinois at Urbana-Champaign

Research Interests:Our research group is interested in inhibiting protein-protein interactions implicated in the progression of certain types of cancer, particularly hormone-responsive and -refractory cancers.  Specifically, we are interested in inhibiting the Nrf2/Keap1 interaction, an interaction involved in various disease states because of Nrf2’s central role in regulating the cell’s response to reactive species. The second project is focused on inhibiting the interactions of nuclear receptors with coactivators. We study these interactions using fluorescence-based assays, and the lab uses the tools of synthetic medicinal chemistry to develop both small molecule- and peptide-based inhibitors.
twmoore@uic.edu

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Brian Murphy

Murphy, Brian T.: Associate Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2007) Virginia Tech

Research interests: The surfaces of marine organisms provide a source of nutrients for microbes within our oceans. Consequently a competition for space results between surface-colonizing (epibiotic) microorganisms. We propose that select secondary metabolites from epibiotic bacteria, which serve as chemical defenses or means of inter- and intra-species microbial communication, can be utilized to probe and combat the pathogenic mechanisms of human microbial pathogens. In the Murphy lab, these epibiotic bacteria are collected from unique source organisms, cultivated in liquid culture, crudely separated, and screened against a variety of human pathogens with the ultimate intent of discovering novel antibiotic structural classes. Of particular interest is the target Mycobacterium tuberculosis, a pathogen responsible for 1.5 ­ 2.3 million deaths in 2008 [WHO Global Tuberculosis Control report]. We work in close collaboration with the Institute for Tuberculosis Research at UIC (http://www.tuberculosisdrugresearch.org/), who has both in vitro and in vivo screening capacity. 
btmurphy@uic.edu

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Jimmy Orjala

Orjala, Jimmy: Associate Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1993) Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.

Research interests: Our research is focused on three areas: 1. Discovery of pharmacological active natural products from cultured cyanobacteria. 2. Chemical communication between microorganisms and its role in the phenomenon of ‘uncultivable’ microorganisms. 3. Novel antineoplastic agents from higher plants. Our research tools are modern chromatographic methods coupled with sensitive analytical techniques, such as microcoil NMR techniques, and molecular target assays. 
orjala@uic.edu

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Guido Pauli

Pauli, Guido F.: Norman R. Farnsworth Professor of Pharmacognosy Professor and University Scholar, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1993) Heinrich Heine–University Düsseldorf; Pharm.D., 1988, Philipps University Marburg..

Research interests: Within the realm of modern pharmacognosy, investigation of traditional as well as novel natural products by means of chemical, biological, pharmacological and metabolome analysis. Research tools are computer-aided structure elucidation, multidimensional andquantitative NMR, modern chromatographic methods includingcountercurrent chromatography, in tandem with in vitro and in vivo biology and pharmacology as well as microbiological methods. Relying on this tool chest, research focuses are in phytopharmacy and phytochemistry, herbal dietary supplements, reference materials, anti-TB drugs and mycobacterial secondary metabolites. 
gfp@uic.edu

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Pavel Petukhov

Petukhov, Pavel A.: Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1998) Novosibirsk Institute of Organic Chemistry, Russia

Research Interests: Development of new methods and biologically orthogonal chemical tools for chemical biology and translation of this knowledge to discovery of novel therapeutically relevant compounds; structure-, ligand-, and fragment-based drug design using a mix of medicinal chemistry, computer-aided drug design, and bioinformatics. The current focus of the laboratory is on the development of methods for characterization of multiple binding modes of the ligands in the binding sites of histone deacetylases (HDAC) using photoactivatable chemical probes and discovery of novel inhibitors of HDACs, calpain, beta-secretases 1 and 2, pantothenate synthetase, and malate synthase with potential application in cancer, neurological and bacterial diseases. 
pap4@uic.edu

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Andrew Riley

Riley, Andrew P.: Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2015) University of Kansas

Research interests: Research in the Riley Lab is focused on the investigation of small molecules inspired by natural products. Employing the tools of modern synthetic and medicinal chemistry we aim to access natural products and their derivatives to investigate how they interact with their macromolecular targets. In doing so, we look to answer important biological questions and provide novel treatment options in the areas of pain and cancer.
apriley@uic.edu

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Laura Sanchez

Sanchez, Laura M.: Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2012) University of California, Santa Cruz, California

Research Interests: The Sanchez lab utilizes cutting edge mass spectrometry techniques to study the chemical language microbes use to communicate with one another and their surroundings. We aim to exploit this chemical communication to understand how microbes function in and affect a host in different health and disease states. Overall, this research will lead to the rapid identification of harmful bacteria based on the chemicals they produce, permitting clinicians and researchers to design more effective courses of treatment. Our work is very interdisciplinary and encompasses aspects of chemical biology, natural products discovery, mass spectrometry (molecular networking and imaging mass spectrometry), host biology, and genome mining.  
sanchelm@uic.edu

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Doel Soejarto

Soejarto, D. Doel: Professor Emeritus, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1969) Harvard University

Research interests: Taxonomy and conservation of plants, with special focus in Southeast Asia, particularly, Vietnam and Laos, and study of plants used in indigenous therapy, as well as tropical rainforest explorations of new and potential medicinal plants (bioprospecting), as part of collaborative research projects at UIC. I also study the taxonomy of the family Actinidiaceae. Since 1998, I have been directing an international collaborative program to study the biodiversity of Vietnam and Laos, as part of the International Cooperative Biodiversity Groups (ICBG) Program (http://www.fic.nih.gov/programs/icbg.html and http://www.uic.edu/pharmacy/research/icbg/ICBG.htm) of the Fogarty International Center, NIH. Our ICBG program activities include floristics and conservation at Cuc Phuong National Park; studies of medicinal plants of Laos; biological evaluation of plants of Vietnam and Laos using anti-HIV, anticancer, anti-TB and anti-malarial bioassays toward the discovery of biologically active molecules as potential candidates for pharmaceutical development; and the promotion of economic development among communities in Vietnam and Laos, where our ICBG work is being undertaken. Aside from UIC as base institution, our ICBG consortium members include Purdue University, Vietnamese Academy of Science and Technology in Hanoi (Institute of Biotechnology, Institute of Chemistry, and Institute of Ecology and Biological Resources), Cuc Phuong National Park (Vietnam), Traditional Medicine Research Center in Vientiane (Laos), and Bristol-Myers Squibb Co. (industrial partner). 
DDS@uic.edu

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Gregory Thatcher

Thatcher, Gregory R.J.: Professor and Hans W. Vahlteich Chair in Medicinal Chemistry; Assistant Head, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1986) University of Toronto

Research interests: Employing the tools of mechanistic organic chemistry and the ability to synthesize novel compounds, biomimetics are being developed as probes of biological systems. These mimetics have the capacity to further understanding of biological processes, chemical toxicology and in some cases to provide new drug candidates. This program is revealing new therapeutics for neurological disorders and for cancer.
thatcher@uic.edu

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Douglas Thomas

Thomas, Douglas D.: Associate Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (2000) Louisiana State University

Research interests: Our goal is to elucidate fundamental mechanisms to explain the etiologies of cancer. In addition to gene mutations, aberrant epigenetic modifications also play major roles in cancer development and progression. The primary focus of this lab is to investigate the myriad of abnormal epigenetic modifications that have been associated with tumor phenotype via tumor suppressor silencing or upregulation of oncogenic proteins. Our approach uses both in vitro and in vivo model systems coupled with a multitude of methodologies including mass spectroscopy, confocal microscopy, electron paramagnetic resonance imaging of free radicals, chemiluminescence, electrochemical, and molecular biology techniques. The current emphasis of our team focuses on genome-wide analysis of events leading to the development and ultimate treatment of breast cancer.
ddthomas@uic.edu

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Charles Woodbury

Woodbury, Charles P.: Associate Professor Emeritus, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1975) University of Wisconsin.

Research interests: Biophysical chemistry of proteins and nucleic acids; electrolyte and polyelectrolyte solutions; macromolecular binding theory; stochastic theory of single molecule reaction kinetics; statistical theory of chromatography. Studies in these fundamental areas will help in the future development of therapeutics and diagnostics. 
woodbury@uic.edu

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Emeriti

Ludwig Bauer Bauer, Ludwig
Audrey Bingel Bingel, Audrey S.
G.A. Cordell Cordell, Geoffrey A.
John Fitzloff Fitzloff, John F.
Harry Fong Fong, Harry H.S.
Tony Hopfinger Hopfinger, Anton J.
Mike Johnson Johnson, Michael E.
Alan Kozikowski Kozikowski, Alan P.
Matthias Lu Lu, Matthias C.
Doel Soejarto Soejarto, Djaja Djendoel
Chuck Woodbury Woodbury, Charles P.

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Research Faculty

Name Research Group Affiliation
Manel Ben Aissa Ben Aissa, Manel
benaissa@uic.edu
Thatcher/UICENTRE
Jonathan Bisson Bisson, Jonathan
bjo@uic.edu
Pauli
Laura Bloem Bloem, Laura
lbloem@uic.edu
 
Thatcher/UICENTRE
Jennifer Chang Chang, Jennifer
j2chang@uic.edu
Federle
Shaonong Chen Chen, Shaonong
sc4sa@uic.edu
Pauli
George Chlipala Chlipala, George
gchlip2@uic.edu
Orjala
Sang Hyun Cho Cho, Sang Hyun
jkcno1@uic.edu
Institute for Tuberculosis Research
Birgit Dietz Dietz, Birgit M.
birgitd@uic.edu
Bolton
Tareisha Dunlap Dunlap, Tareisha
tdunla3@uic.edu
Bolton
Irina Gaisina Gaisina, Irina N.
igaysina@uic.edu
UICENTRE
James Graham Graham, James G.
ucayali@uic.edu
NAPRALERT
Charlotte Gyllenhaal Gyllenhaal, Charlotte
gyllenha@uic.edu
Birgit Jaki Jaki, Birgit U.
bjaki@uic.edu
Institute for Tuberculosis Research
Larry Klein Klein, Larry L.
llk@uic.edu
Institute for Tuberculosis Research
Aleksej Krunic Krunic, Aleksej
akrunic@uic.edu
NMR, Shared Laboratory Resources
David Lankin Lankin, David C.
lankindc@uic.edu
Pauli
Lee, Hyun
danielhl@uic.edu
Jim McAlpine McAlpine, James B.
mcalpine@uic.edu
Pauli
Farah Movahedzadeh Movahed Zadeh, Farahnaz
movahed@uic.edu
Institute for Tuberculosis Research
Dejan Nikolic Nikolic, Dejan S.
dnikol1@uic.edu
van Breemen
Mass Spec Facility
Colleen Piersen Piersen, Colleen E.
cpiersen@uic.edu
Kiira Ratia Ratia, Kiira M.
kratia@uic.edu
UICENTRE
Russo, Angela
russoa@uic.edu
Burdette
Bernie Santarsiero Santarsiero, Bernard D.
bds@uic.edu
RRC Macromolecular Structure Facility
RRC Small Molecule X-ray Facility
Center for Biomolecular Sciences

Pradeep Kumar Singh
Singh, Pradeep Kumar
singhpk@uic.edu
DiMagno
Nora Vazquez-Laslop Vazquez-Laslop, Nora
nvazquez@uic.edu
Center for Biomolecular Sciences

Rui Xiong
Xiong, Rui
rxiong3@uic.edu
Thatcher/UICENTRE

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Adjunct Faculty

Cingy Angerhofer Angerhofer, Cindy K. Aveda Institute / Aveda Corporation
Aldwin Anterola Anterola, Aldwin
Daniel Becker Becker, Daniel P. MDCH 594
Keith Block Block, Keith I. 
male icon Cook, Chyung MDCH 594
Paul Cox Cox, Paul Alan
male icon Cullum, Malford E. 
William Dunn Dunn, William J.
 
Michael Flavin Fabricant, Daniel S. Division Director, Food and Drug Administration (FDA)
Michael Flavin Flavin, Michael T.  Advanced Life Sciences, Inc.
male icon Friesen, John B.
Charlotte Gyllenhaal Gyllenhaal, Charlotte
gyllenha@uic.edu
NAPRALERT, ICBG
male icon Hansen, Donald W. Jr. MDCH 594
Doug Kinghorn Kinghorn, A. Douglas The Ohio State University
Bill Marks Marks, William H. Swedish Medical Center
Jim McAlpine McAlpine, James B.
Richard Moon Mesecar, Andrew D. Purdue University
Richard Moon Moon, Richard
Yuan Ping Pang Pang, Yuan-Ping Mayo Clinic College of Medicine
John Pezzuto Pezzuto, John M. University of Hawaii Hilo
Barry Pitzele Pitzele, Barnett S. MDCH 594, PHAR 331 (Fall 2008-2010)
Steve Swanson Swanson, Steven M. University of Wisconsin
Duane Venton Venton, Duane L.
male icon Woodford, Mark M.  
Joseph Zhou Zhou, Zi (Joseph) Now Foods
 
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